Metrohm NanoRam 1064
Handheld Raman Spectrometer for Raw Material Identification
Fast, non-destructive 1064 nm Raman identification and verification of pharmaceutical and industrial raw materials, with sampling accessories selected around the actual sample and packaging.
The NanoRam-1064 Flex combines the proven NanoRam-1064 platform with a configurable package that allows laboratories to select only the sampling attachments required for their workflow. It is particularly suited to APIs, excipients, intermediates, colored materials and high-fluorescence samples that can be difficult for shorter-wavelength handheld Raman systems.
- 1064 nm excitation to minimize fluorescence from colored and difficult materials
- Non-destructive measurement directly or through transparent glass and plastic packaging
- 21 CFR Part 11-compliant embedded and PC software with audit trail and electronic report signing
- Configurable sampling attachments for bags, vials, bottles, drums, powders, liquids, gels and solids
- User-definable methods and libraries with clear pass/fail verification results
- Rugged IP65 handheld design for warehouse, loading-dock, sampling-booth, laboratory and field use
Supplied and supported in Pakistan by Continental Worldwide Trading Company (CWTC).
Key Features
1064 nm Fluorescence Reduction
Longer-wavelength excitation minimizes fluorescence from colored, excipient-rich and otherwise difficult samples, expanding the range of materials that can be identified by handheld Raman.
Non-Destructive Through-Container Testing
Many raw materials can be measured directly or through transparent glass and plastic packaging, reducing sample handling, exposure and contamination risk.
Configurable Flex Sampling
The user selects point-and-shoot, vial, bottle, large-bottle, immersion, right-angle or large-spot attachments according to sample form, container and working environment.
21 CFR Part 11 Data Integrity
NOS-1064 and NID EX support secure records, complete audit trails, electronic report signing, user controls and centralised data and report management.
Clear Pass/Fail Verification
Reduced-variable multivariate methods use representative spectra and natural lot variation to provide statistically based pass/fail verification results.
Pharmacopeial Performance Support
Performance validation is designed around major Raman pharmacopeial methods, with qualification documentation and implementation services available.
Onboard Methods and Libraries
The embedded software supports identification, verification, library development, method development and validation, and transfer of methods and library entries between devices.
Warehouse-Ready Operation
A bright touchscreen, one-touch workflow, 1D/2D barcode reader, batch mode and single-handed design allow trained non-spectroscopists to perform routine tests.
Method Transfer and Deployment
Libraries and validated methods can be transferred across instruments to support harmonised operation across warehouses, plants or multiple sites.
Where the NanoRam 1064 fits in laboratory workflows
Pharmaceutical Incoming Raw-Material Identification
Rapid verification of APIs, excipients and intermediates at goods receipt, quarantine, warehouse or dispensing areas. The operator can select a validated method by barcode, scan the material and obtain a clear pass/fail result.
High-Fluorescence Excipients and Colored Materials
1064 nm excitation improves the ability to verify materials such as cellulose derivatives, polysorbates, coated excipients, Opadry® materials, pigments and other samples that may fluoresce strongly with shorter Raman wavelengths.
100% Container or Batch-Sampling Workflows
Handheld operation supports identity testing at the container rather than moving all containers to a central lab. The exact sampling plan remains subject to the customer’s GMP procedures and applicable regulations.
Personal Care, Food and Ingredient Verification
Screening and identity verification of ingredients where Raman response, packaging and method specificity are suitable. Application feasibility should be confirmed with representative samples.
Chemical and Industrial Raw Materials
Identification of solvents, organic and inorganic chemicals, polymers, additives, dyes, pigments and related production materials using customer-built or optional spectral libraries.
Key Product Features
NanoRam-1064 Flex Base Scope
Standard components included with the Flex configuration
- NanoRam-1064 instrument platform
- Polystyrene Validation CapBWT-840000348
- 8V rechargeable lithium-ion batteryBWT-840000403
- 18V power adapter with international plugsBWT-840000414
- USB cableBWT-840000858
Sampling attachment selection matrix
Point-and-Shoot Adapter
Typical Sample or ContainerDirect measurement of powders, solids and materials in suitable transparent bags or containers
Practical ReasonFast general-purpose sampling with minimal handling
Vial Holder Adapter
Typical Sample or ContainerLiquids or powders transferred to compatible 15 mm vials
Practical ReasonStable, repeatable vial positioning; compatible vials are available
Bottle Adapter
Typical Sample or ContainerMaterials in standard bottles or containers
Practical ReasonImproves positioning and repeatability against a container wall
Large Bottle Adapter, 1064
Typical Sample or ContainerLarger bottles and containers
Practical Reason10 mm working distance for larger-container sampling
1064 Immersion Probe
Typical Sample or ContainerLiquids, gels or materials requiring contact or deeper sampling in bottles and drums
Practical Reason6-inch contact probe; approximately 1 mm working distance; up to 2 bar at room temperature
Right-Angle Adapter
Typical Sample or ContainerHands-free or bench-supported measurement
Practical ReasonUseful where stable positioning is preferred
Large Spot Adapter
Typical Sample or ContainerDark, sensitive or heterogeneous materials
Practical ReasonLarger spot and greater sampling depth can reduce burning risk and improve representative sampling
Polystyrene Validation Cap
Typical Sample or ContainerInstrument performance validation
Practical ReasonIntegrated ASTM-standard polystyrene; included in Flex base scope
Complementary Products, Software and Accessories
Power and Portability
Battery charging cradle, spare rechargeable battery, rugged carrying case, shoulder bag and adapter pouches for warehouse and multi-location use.
Optional Spectral Libraries
USP, API, polymers, dyes and pigments, pesticides, biochemicals, personal care, inorganics and comprehensive chemical libraries.
Frequently Asked Question
1064 nm excitation produces less fluorescence from many colored, excipient-rich and difficult materials. This can allow Raman identification where fluorescence from shorter wavelengths obscures the chemical fingerprint. For pharmaceutical it allows you freedom to virtual measure any raw material including dyes, colored samples, tablet coatings (eg. Opadry)
It can measure many materials through transparent glass and plastic containers or bags. Packaging thickness, colour, additives, surface condition and sample position can affect the result. It should not be described as a universal through-opaque-container analyzer
Metrohm states that the NOS-1064 embedded software and NID EX PC software are 21 CFR Part 11 compliant. NID EX provides a secure database, complete audit trail and electronic report signing. The customer must still validate and control the complete operating process.
Metrohm states that NanoRam-1064 meets the requirements of USP <858>, European Pharmacopoeia 2.2.48, Japanese Pharmacopoeia 2.26 and Chinese Pharmacopoeia Raman guidance. Final use must follow the customer’s applicable monograph, SOP and validation plan.
Yes. NanoRam supports method and library transfer between devices, which can help standardise testing across departments, plants or multiple sites after appropriate validation and change control.
Local supply and support in Pakistan
CWTC supports Raman users in Pakistan with product selection, application discussion, quotation, supply, installation where applicable, operator training, accessory selection and after-sales coordination.
- Application review and selection of the NanoRam-1064 Flex package and suitable sampling attachments
- Demonstration or feasibility testing with representative customer materials where practical
- Method and library development support using representative lots and natural material variation
- Installation, user setup, barcode workflow configuration and operator training
- NID EX software setup, data-transfer workflow and LIMS/interface discussion
- IQ/OQ/PQ/DQ implementation scope and performance-validation support where included in the quotation
- Support for SOP development, method transfer and deployment across multiple instruments or sites where separately agreed
- Supply of replacement batteries, vials, validation caps, adapters and related accessories
- Preventive maintenance, troubleshooting, repair coordination and annual performance-validation planning
Product selectionApplication consultationDemonstrationInstallationOperator trainingTechnical support
Documentation & Downloads
Use the official Metrohm resources below for the latest technical specifications, manuals and product documentation.
Need Expert Advice?
CWTC can help you with your application or any queries related to our equipment or your lab requirement, connect with our product experts on the contact information below.
